Azilsartan is a white to off-white crystalline powder, odorless and tasteless. It is a new generation of selective angiotensin II type 1 (AT1) receptor antagonist. By blocking the binding of angiotensin II to its receptors, it inhibits vasoconstriction and aldosterone release, thereby achieving stable blood pressure reduction.
Chemical Name: 2-ethoxy-1-[[2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid.
Physical & Chemical Properties
Molecular FormulaC25H20N4O5
Density:1.42g/cm³g/cm³
Boiling Point:
Solubility:
Practically insoluble in water and acetone, slightly soluble in ethanol, methanol and acetonitrile, and freely soluble in dimethyl sulfoxide (DMSO).
Molecular Weight:456.45g/mol
Flash Point:
Melting Point:188℃
Uses
1. Clinical: For the treatment of essential hypertension. As a long-acting antihypertensive agent, it is administered once daily, reaches peak effect in 2 hours, and lasts for more than 24 hours.
2. Pharmaceutical: Used in the preparation of oral preparations such as Azilsartan Medoxomil Potassium Tablets to reduce the risk of cardiovascular events.
3. R&D: Used as a reference standard / control substance for sartan drugs, in pharmaceutical analysis, impurity research and preclinical trials.